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Guanfacine vs Clonidine: Recognizing the Differences for ADHD Treatment in New York City highlights the key distinctions between these two alpha-2 adrenergic agonists commonly used to manage ADHD symptoms. Both guanfacine and clonidine act on alpha-2 receptors but differ in their receptor selectivity and side effect profiles. Guanfacine is more selective for the α2A receptor subtype, which enhances prefrontal cortex functions such as attention and impulse control, making it a preferred choice for many patients in New York City seeking effective ADHD management. Meanwhile, clonidine binds more broadly and is about ten times more potent at presynaptic receptors
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