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Acetaminophen and oxycodone are the two main ingredients in the prescription drug Percocet. Strong opioid painkiller oxycodone is combined with less strong painkiller acetaminophen to increase the effects of both drugs.

When other painkillers are ineffective at relieving moderate-to-severe pain, Percocet is typically used. It is frequently prescribed following surgery, trauma, or chronic pain conditions for which non-opioid painkillers are insufficient.
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